Drug interactions
Loxapine + Lurasidone
Severity: Moderate
Loxapine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two antipsychotics are used together, which adds to sedation, orthostatic hypotension, extrapyramidal symptoms and the risk of neuroleptic malignant syndrome. Combination therapy generally increases adverse effect burden without proven additional benefit.
What this interaction means in plain words
Loxapine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive dopamine D2 antagonism and additive CNS depressant and alpha-adrenergic effects.
What to do
Avoid antipsychotic polypharmacy where possible and use the lowest effective doses. Monitor for sedation, orthostasis, movement disorders and signs of neuroleptic malignant syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Loxapine with Lurasidone?
MediHelp rates the interaction as moderate. Loxapine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two antipsychotics are used together, which adds to sedation, orthostatic hypotension, extrapyramidal symptoms and the risk of neuroleptic malignant syndrome. Combination therapy generally increases adverse effect burden without proven additional benefit.
How serious is the interaction between Loxapine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy where possible and use the lowest effective doses. Monitor for sedation, orthostasis, movement disorders and signs of neuroleptic malignant syndrome.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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