Drug interactions
Loxapine + Meperidine
Severity: Moderate
Loxapine and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine adds to the sedative, hypotensive and respiratory depressant effects of meperidine. Serotonin syndrome or neuroleptic malignant syndrome is a rare concern.
What this interaction means in plain words
Loxapine and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression with possible serotonergic and dopaminergic overlap.
What to do
Begin with reduced opioid doses and monitor sedation, respiration and blood pressure. Watch for hyperthermia, rigidity or clonus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Meperidine?
MediHelp rates the interaction as moderate. Loxapine and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine adds to the sedative, hypotensive and respiratory depressant effects of meperidine. Serotonin syndrome or neuroleptic malignant syndrome is a rare concern.
How serious is the interaction between Loxapine and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin with reduced opioid doses and monitor sedation, respiration and blood pressure. Watch for hyperthermia, rigidity or clonus.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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