Drug interactions
Loxapine + Nabilone
Severity: Moderate
Loxapine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so concurrent use may increase drowsiness and impair alertness and coordination. Cannabinoids may also aggravate psychotic symptoms, and additive effects on heart rate and blood pressure are possible.
What this interaction means in plain words
Loxapine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression, with possible additive anticholinergic and hypotensive effects.
What to do
Monitor sedation, blood pressure and psychiatric status, and use low starting doses. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Nabilone?
MediHelp rates the interaction as moderate. Loxapine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so concurrent use may increase drowsiness and impair alertness and coordination. Cannabinoids may also aggravate psychotic symptoms, and additive effects on heart rate and blood pressure are possible.
How serious is the interaction between Loxapine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and psychiatric status, and use low starting doses. Advise against driving until the response is known.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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