Drug interactions
Loxapine + Solifenacin
Severity: Moderate
Loxapine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine has anticholinergic activity, so adding solifenacin increases the risk of dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia. Both drugs may also affect QT interval, and the effect is more pronounced in older adults.
What this interaction means in plain words
Loxapine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects, with possible additive QT effects.
What to do
Monitor for anticholinergic toxicity, especially urinary retention and cognitive changes, and consider an ECG in patients with cardiac risk factors. Prefer a non-anticholinergic bladder agent if symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Solifenacin?
MediHelp rates the interaction as moderate. Loxapine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine has anticholinergic activity, so adding solifenacin increases the risk of dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia. Both drugs may also affect QT interval, and the effect is more pronounced in older adults.
How serious is the interaction between Loxapine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially urinary retention and cognitive changes, and consider an ECG in patients with cardiac risk factors. Prefer a non-anticholinergic bladder agent if symptoms emerge.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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