Drug interactions
Loxapine + Temazepam
Severity: Moderate
Loxapine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine and temazepam both cause sedation, and combined use can increase drowsiness, psychomotor impairment and, in some cases, respiratory depression. Older patients and those with respiratory disease are at higher risk.
What this interaction means in plain words
Loxapine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A enhancement and antihistaminic or antiadrenergic effects of loxapine.
What to do
Use the lowest effective doses and monitor for oversedation and respiratory compromise. Advise the patient against driving or using alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Loxapine with Temazepam?
MediHelp rates the interaction as moderate. Loxapine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine and temazepam both cause sedation, and combined use can increase drowsiness, psychomotor impairment and, in some cases, respiratory depression. Older patients and those with respiratory disease are at higher risk.
How serious is the interaction between Loxapine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and respiratory compromise. Advise the patient against driving or using alcohol.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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