Drug interactions
Loxapine inhaled + Prochlorperazine
Severity: Moderate
Loxapine inhaled and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dopamine-blocking antipsychotics, so combining them increases the risk of extrapyramidal symptoms, neuroleptic malignant syndrome and sedation. Inhaled loxapine can also cause bronchospasm, and systemic exposure is substantial.
What this interaction means in plain words
Loxapine inhaled and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopamine D2 receptor antagonism and CNS depression.
What to do
Monitor for extrapyramidal symptoms, rigidity, fever and excessive sedation. Avoid additional antipsychotics where possible, and monitor the ECG if other QT-prolonging risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Loxapine inhaled with Prochlorperazine?
MediHelp rates the interaction as moderate. Loxapine inhaled and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are dopamine-blocking antipsychotics, so combining them increases the risk of extrapyramidal symptoms, neuroleptic malignant syndrome and sedation. Inhaled loxapine can also cause bronchospasm, and systemic exposure is substantial.
How serious is the interaction between Loxapine inhaled and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, rigidity, fever and excessive sedation. Avoid additional antipsychotics where possible, and monitor the ECG if other QT-prolonging risk factors are present.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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