Drug interactions
Loxapine inhaled + Vilazodone
Severity: Moderate
Loxapine inhaled and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonergic antidepressants combined with dopamine-blocking antipsychotics can rarely lead to serotonin syndrome or neuroleptic malignant syndrome. Inhaled loxapine also causes sedation, which may be additive with vilazodone.
What this interaction means in plain words
Loxapine inhaled and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic interaction between serotonergic enhancement and dopamine blockade, with additive sedation.
What to do
Monitor for mental status changes, hyperthermia, rigidity and autonomic instability. Stop the agents if serotonin syndrome or NMS is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Loxapine inhaled with Vilazodone?
MediHelp rates the interaction as moderate. Loxapine inhaled and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonergic antidepressants combined with dopamine-blocking antipsychotics can rarely lead to serotonin syndrome or neuroleptic malignant syndrome. Inhaled loxapine also causes sedation, which may be additive with vilazodone.
How serious is the interaction between Loxapine inhaled and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status changes, hyperthermia, rigidity and autonomic instability. Stop the agents if serotonin syndrome or NMS is suspected.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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