Drug interactions
Lumacaftor / ivacaftor + Montelukast
Severity: Minor
Lumacaftor / ivacaftor and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor induces CYP3A4 and possibly CYP2C enzymes, which may lower montelukast exposure, while ivacaftor has weak inhibitory effects. The net result is probably a small, clinically minor change in montelukast effect.
What this interaction means in plain words
Lumacaftor / ivacaftor and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lumacaftor induces CYP3A4 and CYP2C enzymes, while ivacaftor weakly inhibits CYP2C9, giving an uncertain net effect on montelukast clearance.
What to do
No dose adjustment is recommended; assess asthma control and consider a dose review if response appears diminished.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Montelukast?
MediHelp rates the interaction as minor. Lumacaftor / ivacaftor and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumacaftor induces CYP3A4 and possibly CYP2C enzymes, which may lower montelukast exposure, while ivacaftor has weak inhibitory effects. The net result is probably a small, clinically minor change in montelukast effect.
How serious is the interaction between Lumacaftor / ivacaftor and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is recommended; assess asthma control and consider a dose review if response appears diminished.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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