Drug interactions
Lumacaftor / ivacaftor + Progesterone
Severity: Moderate
Lumacaftor / ivacaftor and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and can lower progesterone exposure, reducing hormonal efficacy. Hormonal contraceptives are labeled as unreliable with this combination.
What this interaction means in plain words
Lumacaftor / ivacaftor and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP3A4 (and other enzymes), increasing progesterone metabolism.
What to do
Use a non-hormonal contraceptive method if contraception is the purpose, and monitor for loss of progestogen effect, adjusting the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Progesterone?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and can lower progesterone exposure, reducing hormonal efficacy. Hormonal contraceptives are labeled as unreliable with this combination.
How serious is the interaction between Lumacaftor / ivacaftor and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal contraceptive method if contraception is the purpose, and monitor for loss of progestogen effect, adjusting the dose if needed.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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