Drug interactions
Lurasidone + Maprotiline
Severity: Moderate
Lurasidone and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents act on the central nervous system, so together they may increase drowsiness, dizziness and impaired psychomotor performance. Orthostatic hypotension may also be additive, and maprotiline lowers the seizure threshold.
What this interaction means in plain words
Lurasidone and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depressant and receptor blocking effects; no pharmacokinetic interaction is established.
What to do
Monitor for sedation, dizziness and orthostatic blood pressure changes, especially when starting or adjusting doses. Counsel on driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Maprotiline?
MediHelp rates the interaction as moderate. Lurasidone and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents act on the central nervous system, so together they may increase drowsiness, dizziness and impaired psychomotor performance. Orthostatic hypotension may also be additive, and maprotiline lowers the seizure threshold.
How serious is the interaction between Lurasidone and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and orthostatic blood pressure changes, especially when starting or adjusting doses. Counsel on driving and alcohol.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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