Drug interactions
Lurasidone + Methohexital
Severity: Moderate
Lurasidone and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic, and lurasidone adds to sedation and may add to hypotension. Deeper or longer-lasting sedation and cardiorespiratory depression are possible.
What this interaction means in plain words
Lurasidone and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hypotensive effects.
What to do
Titrate methohexital carefully to effect with continuous monitoring of respiration, oxygen saturation and blood pressure; a lower anesthetic dose may suffice.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Lurasidone with Methohexital?
MediHelp rates the interaction as moderate. Lurasidone and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic, and lurasidone adds to sedation and may add to hypotension. Deeper or longer-lasting sedation and cardiorespiratory depression are possible.
How serious is the interaction between Lurasidone and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully to effect with continuous monitoring of respiration, oxygen saturation and blood pressure; a lower anesthetic dose may suffice.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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