Drug interactions
Lurasidone + Nadolol
Severity: Moderate
Lurasidone and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause orthostatic hypotension through alpha-1 blockade, which may add to the blood pressure lowering effect of nadolol. Dizziness, syncope and falls are the main concerns, especially at initiation or dose increases.
What this interaction means in plain words
Lurasidone and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Nadolol belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from antipsychotic alpha-adrenergic blockade and beta-blockade.
What to do
Monitor blood pressure and orthostatic symptoms during lurasidone initiation and titration, and reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Nadolol
Frequently asked questions
Can I take Lurasidone with Nadolol?
MediHelp rates the interaction as moderate. Lurasidone and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause orthostatic hypotension through alpha-1 blockade, which may add to the blood pressure lowering effect of nadolol. Dizziness, syncope and falls are the main concerns, especially at initiation or dose increases.
How serious is the interaction between Lurasidone and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms during lurasidone initiation and titration, and reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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