Drug interactions
Lurasidone + Naratriptan
Severity: Minor
Lurasidone and Naratriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans combined with antipsychotics have a theoretical risk of serotonin syndrome, although clinical reports are rare. Lurasidone has 5-HT1A partial agonism and 5-HT2A and 5-HT7 antagonism, so the risk appears low.
What this interaction means in plain words
Lurasidone and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lurasidone belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; the mechanism is largely theoretical.
What to do
No routine change is needed; educate patients to seek care for agitation, tremor, fever or sweating after starting the combination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Lurasidone with Naratriptan?
MediHelp rates the interaction as minor. Lurasidone and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triptans combined with antipsychotics have a theoretical risk of serotonin syndrome, although clinical reports are rare. Lurasidone has 5-HT1A partial agonism and 5-HT2A and 5-HT7 antagonism, so the risk appears low.
How serious is the interaction between Lurasidone and Naratriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; educate patients to seek care for agitation, tremor, fever or sweating after starting the combination.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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