Drug interactions
Lurasidone + Nicardipine
Severity: Moderate
Lurasidone and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weak to moderate CYP3A4 inhibitor and can raise lurasidone concentrations. This may increase adverse effects such as sedation, akathisia and extrapyramidal symptoms.
What this interaction means in plain words
Lurasidone and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lurasidone.
What to do
Consider reducing the lurasidone dose when starting nicardipine, as labeling advises for moderate CYP3A4 inhibitors. Monitor for sedation and movement disorders.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Nicardipine?
MediHelp rates the interaction as moderate. Lurasidone and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine is a weak to moderate CYP3A4 inhibitor and can raise lurasidone concentrations. This may increase adverse effects such as sedation, akathisia and extrapyramidal symptoms.
How serious is the interaction between Lurasidone and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the lurasidone dose when starting nicardipine, as labeling advises for moderate CYP3A4 inhibitors. Monitor for sedation and movement disorders.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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