Drug interactions
Lurasidone + Orphenadrin
Severity: Moderate
Lurasidone and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause somnolence and orthostatic hypotension, and orphenadrine adds sedation and anticholinergic effects. Together they may cause more drowsiness, dizziness and confusion.
What this interaction means in plain words
Lurasidone and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive CNS depressant and antimuscarinic effects.
What to do
Monitor for sedation, orthostatic hypotension and anticholinergic effects. Reduce orphenadrine dose or stop it if cognitive impairment appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lurasidone and Orphenadrin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Orphenadrin
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Orphenadrin?
MediHelp rates the interaction as moderate. Lurasidone and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause somnolence and orthostatic hypotension, and orphenadrine adds sedation and anticholinergic effects. Together they may cause more drowsiness, dizziness and confusion.
How serious is the interaction between Lurasidone and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and anticholinergic effects. Reduce orphenadrine dose or stop it if cognitive impairment appears.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
