Drug interactions
Lurasidone + Pramipexole
Severity: Moderate
Lurasidone and Pramipexole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone blocks dopamine D2 receptors and may reduce the effect of the dopamine agonist pramipexole, with possible worsening of parkinsonian symptoms. Pramipexole may in turn aggravate psychosis, and both can contribute to sedation and orthostatic hypotension.
What this interaction means in plain words
Lurasidone and Pramipexole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Pramipexole belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors, with additive sedative and hypotensive effects.
What to do
Monitor motor function, psychotic symptoms and orthostatic blood pressure; in Parkinson disease, prefer an antipsychotic with lower D2 liability such as quetiapine or clozapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Frequently asked questions
Can I take Lurasidone with Pramipexole?
MediHelp rates the interaction as moderate. Lurasidone and Pramipexole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone blocks dopamine D2 receptors and may reduce the effect of the dopamine agonist pramipexole, with possible worsening of parkinsonian symptoms. Pramipexole may in turn aggravate psychosis, and both can contribute to sedation and orthostatic hypotension.
How serious is the interaction between Lurasidone and Pramipexole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor function, psychotic symptoms and orthostatic blood pressure; in Parkinson disease, prefer an antipsychotic with lower D2 liability such as quetiapine or clozapine.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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