Drug interactions
Lurasidone + Procarbazine
Severity: Moderate
Lurasidone and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine is a weak monoamine oxidase inhibitor and may cause hypotension or serotonergic effects when combined with antipsychotics. Both drugs can also cause sedation, and the combination adds to orthostatic hypotension risk.
What this interaction means in plain words
Lurasidone and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Additive CNS depression and hypotension, with theoretical serotonergic effects from MAO inhibition.
What to do
Monitor blood pressure, mental status and signs of serotonin toxicity or neuroleptic malignant syndrome; reduce doses or change therapy if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Lurasidone with Procarbazine?
MediHelp rates the interaction as moderate. Lurasidone and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine is a weak monoamine oxidase inhibitor and may cause hypotension or serotonergic effects when combined with antipsychotics. Both drugs can also cause sedation, and the combination adds to orthostatic hypotension risk.
How serious is the interaction between Lurasidone and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, mental status and signs of serotonin toxicity or neuroleptic malignant syndrome; reduce doses or change therapy if symptoms appear.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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