Drug interactions
Lurasidone + Quetiapine
Severity: Moderate
Lurasidone and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two antipsychotics increases sedation, orthostatic hypotension, extrapyramidal effects and metabolic burden. Both have QT-prolonging potential, though modest, and the combination rarely offers added benefit over monotherapy.
What this interaction means in plain words
Lurasidone and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive dopamine, serotonin, histamine and alpha-1 receptor antagonism producing additive CNS and hypotensive effects.
What to do
Avoid antipsychotic polypharmacy when possible; if combined, monitor sedation, blood pressure, movement disorders and metabolic parameters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Lurasidone with Quetiapine?
MediHelp rates the interaction as moderate. Lurasidone and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two antipsychotics increases sedation, orthostatic hypotension, extrapyramidal effects and metabolic burden. Both have QT-prolonging potential, though modest, and the combination rarely offers added benefit over monotherapy.
How serious is the interaction between Lurasidone and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy when possible; if combined, monitor sedation, blood pressure, movement disorders and metabolic parameters.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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