Drug interactions
Lurasidone + Saxagliptin-metformin
Severity: Minor
Lurasidone and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can cause hyperglycemia and weight gain, which may offset the glucose-lowering effect of saxagliptin-metformin. Lurasidone has a comparatively low metabolic risk, so the effect is usually modest.
What this interaction means in plain words
Lurasidone and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lurasidone belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as antipsychotics may induce insulin resistance and impair insulin secretion.
What to do
Monitor fasting glucose and HbA1c at baseline and periodically during lurasidone therapy, and intensify antidiabetic treatment if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Lurasidone and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atypical antipsychotics can cause hyperglycemia and weight gain, which may offset the glucose-lowering effect of saxagliptin-metformin. Lurasidone has a comparatively low metabolic risk, so the effect is usually modest.
How serious is the interaction between Lurasidone and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and periodically during lurasidone therapy, and intensify antidiabetic treatment if control worsens.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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