Drug interactions
Lurasidone + Sertraline
Severity: Minor
Lurasidone and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline is a weak CYP3A4 inhibitor and could modestly raise lurasidone concentrations, and both drugs can cause sedation and akathisia. Clinically significant effects are uncommon at usual doses.
What this interaction means in plain words
Lurasidone and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lurasidone belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline plus additive CNS effects.
What to do
No routine dose change is needed. Monitor for sedation, akathisia and other adverse effects when starting or adjusting doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Sertraline?
MediHelp rates the interaction as minor. Lurasidone and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline is a weak CYP3A4 inhibitor and could modestly raise lurasidone concentrations, and both drugs can cause sedation and akathisia. Clinically significant effects are uncommon at usual doses.
How serious is the interaction between Lurasidone and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for sedation, akathisia and other adverse effects when starting or adjusting doses.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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