Drug interactions
Lurasidone + Sufentanil
Severity: Moderate
Lurasidone and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a potent opioid, and combining it with lurasidone can increase sedation, hypotension and respiratory depression. The risk is highest with higher opioid doses and in debilitated patients.
What this interaction means in plain words
Lurasidone and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive central nervous system and respiratory depressant effects.
What to do
Monitor sedation, respiratory rate and blood pressure, and use the lowest effective sufentanil dose. Make sure monitoring and resuscitation facilities are available in procedural settings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Lurasidone with Sufentanil?
MediHelp rates the interaction as moderate. Lurasidone and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is a potent opioid, and combining it with lurasidone can increase sedation, hypotension and respiratory depression. The risk is highest with higher opioid doses and in debilitated patients.
How serious is the interaction between Lurasidone and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate and blood pressure, and use the lowest effective sufentanil dose. Make sure monitoring and resuscitation facilities are available in procedural settings.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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