Drug interactions
Lurasidone + Sumatriptan
Severity: Minor
Lurasidone and Sumatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics with 5-HT2A antagonism and triptans acting as 5-HT1B/1D agonists have rarely been linked with serotonin syndrome when combined. Evidence of a true clinically significant interaction is limited and the risk appears low.
What this interaction means in plain words
Lurasidone and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lurasidone belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic modulation; the mechanism is not firmly established.
What to do
No routine change is needed; advise patients to report agitation, tremor, fever, diarrhea or rigidity promptly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Lurasidone with Sumatriptan?
MediHelp rates the interaction as minor. Lurasidone and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antipsychotics with 5-HT2A antagonism and triptans acting as 5-HT1B/1D agonists have rarely been linked with serotonin syndrome when combined. Evidence of a true clinically significant interaction is limited and the risk appears low.
How serious is the interaction between Lurasidone and Sumatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; advise patients to report agitation, tremor, fever, diarrhea or rigidity promptly.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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