Drug interactions
Lurasidone + Tetrabenazine
Severity: Moderate
Lurasidone and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, parkinsonism and akathisia, and tetrabenazine may cause depression and QT prolongation. Combined use may heighten somnolence and extrapyramidal effects, and antipsychotics may counteract tetrabenazine's benefit.
What this interaction means in plain words
Lurasidone and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and dopaminergic antagonism or depletion (D2 blockade with VMAT2 inhibition).
What to do
Monitor for sedation, extrapyramidal symptoms, mood changes and QT-related symptoms. Use the lowest effective doses and review the need for both drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lurasidone and Tetrabenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Lurasidone with Tetrabenazine?
MediHelp rates the interaction as moderate. Lurasidone and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, parkinsonism and akathisia, and tetrabenazine may cause depression and QT prolongation. Combined use may heighten somnolence and extrapyramidal effects, and antipsychotics may counteract tetrabenazine's benefit.
How serious is the interaction between Lurasidone and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal symptoms, mood changes and QT-related symptoms. Use the lowest effective doses and review the need for both drugs.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
