Drug interactions
Lurasidone + Tranylcypromine
Severity: Major
Lurasidone and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone labeling advises against use with MAO inhibitors, and the combination may increase serotonergic effects, sedation and orthostatic hypotension. There is also a theoretical risk of neuroleptic malignant syndrome. Clinical data on the specific pair are limited.
What this interaction means in plain words
Lurasidone and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lurasidone belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on monoamine and receptor systems; MAO inhibition combined with lurasidone's serotonin and dopamine receptor activity.
What to do
Avoid the combination where possible and choose an alternative antipsychotic. If it is unavoidable, use low doses and monitor for serotonin toxicity, blood pressure changes and NMS signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Tranylcypromine?
MediHelp rates the interaction as major. Lurasidone and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lurasidone labeling advises against use with MAO inhibitors, and the combination may increase serotonergic effects, sedation and orthostatic hypotension. There is also a theoretical risk of neuroleptic malignant syndrome. Clinical data on the specific pair are limited.
How serious is the interaction between Lurasidone and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative antipsychotic. If it is unavoidable, use low doses and monitor for serotonin toxicity, blood pressure changes and NMS signs.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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