Drug interactions
Lurasidone + Verapamil
Severity: Moderate
Lurasidone and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a moderate CYP3A4 inhibitor and raises lurasidone exposure, which can increase sedation, akathisia, extrapyramidal symptoms and other dose-related adverse effects. Lurasidone may also add to the blood pressure lowering of verapamil, leading to hypotension or orthostasis.
What this interaction means in plain words
Lurasidone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits intestinal and hepatic CYP3A4, reducing lurasidone clearance, and both drugs have additive hypotensive effects.
What to do
Start lurasidone at a reduced dose and keep within the labeled maximum for use with moderate CYP3A4 inhibitors. Monitor for extrapyramidal symptoms, sedation and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Verapamil?
MediHelp rates the interaction as moderate. Lurasidone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil is a moderate CYP3A4 inhibitor and raises lurasidone exposure, which can increase sedation, akathisia, extrapyramidal symptoms and other dose-related adverse effects. Lurasidone may also add to the blood pressure lowering of verapamil, leading to hypotension or orthostasis.
How serious is the interaction between Lurasidone and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start lurasidone at a reduced dose and keep within the labeled maximum for use with moderate CYP3A4 inhibitors. Monitor for extrapyramidal symptoms, sedation and blood pressure.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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