Drug interactions
Lurasidone + Voxelotor
Severity: Moderate
Lurasidone and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can inhibit CYP3A4 and raise exposure to sensitive CYP3A4 substrates such as lurasidone. Higher lurasidone levels increase the risk of sedation, akathisia and extrapyramidal symptoms.
What this interaction means in plain words
Lurasidone and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibition of CYP3A4 reduces lurasidone metabolism.
What to do
Monitor for lurasidone adverse effects and consider a dose reduction if the combination is needed. Reassess if voxelotor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Lurasidone with Voxelotor?
MediHelp rates the interaction as moderate. Lurasidone and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor can inhibit CYP3A4 and raise exposure to sensitive CYP3A4 substrates such as lurasidone. Higher lurasidone levels increase the risk of sedation, akathisia and extrapyramidal symptoms.
How serious is the interaction between Lurasidone and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lurasidone adverse effects and consider a dose reduction if the combination is needed. Reassess if voxelotor is stopped.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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