Drug interactions
Lurasidone + Zafirlukast
Severity: Moderate
Lurasidone and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone is mainly cleared by CYP3A4, so a weak inhibitor like zafirlukast may increase its exposure. This could increase sedation, akathisia and extrapyramidal symptoms.
What this interaction means in plain words
Lurasidone and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Zafirlukast belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated lurasidone metabolism by zafirlukast.
What to do
Monitor for sedation, akathisia and extrapyramidal effects after starting zafirlukast. Reduce the lurasidone dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Zafirlukast?
MediHelp rates the interaction as moderate. Lurasidone and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone is mainly cleared by CYP3A4, so a weak inhibitor like zafirlukast may increase its exposure. This could increase sedation, akathisia and extrapyramidal symptoms.
How serious is the interaction between Lurasidone and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, akathisia and extrapyramidal effects after starting zafirlukast. Reduce the lurasidone dose if adverse effects appear.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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