Drug interactions
Macimorelin + Memantine-donepezil
Severity: Moderate
Macimorelin and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes QT prolongation and donepezil may add to this effect. Combined exposure during the diagnostic test could increase arrhythmia risk.
What this interaction means in plain words
Macimorelin and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Consider withholding donepezil before the test if clinically acceptable, as labeling advises caution with QT-prolonging drugs. Otherwise check the ECG and correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Memantine-donepezil?
MediHelp rates the interaction as moderate. Macimorelin and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin causes QT prolongation and donepezil may add to this effect. Combined exposure during the diagnostic test could increase arrhythmia risk.
How serious is the interaction between Macimorelin and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding donepezil before the test if clinically acceptable, as labeling advises caution with QT-prolonging drugs. Otherwise check the ECG and correct electrolyte abnormalities.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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