Drug interactions
Macimorelin + Mifepristone
Severity: Major
Macimorelin and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and mifepristone may also raise macimorelin concentrations through CYP3A4 inhibition. The combination increases the risk of torsade de pointes.
What this interaction means in plain words
Macimorelin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Mifepristone belongs to Endocrine.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by mifepristone raising macimorelin levels.
What to do
Avoid the combination during macimorelin testing. Allow adequate washout of mifepristone before the test, and use an alternative diagnostic approach if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Mifepristone?
MediHelp rates the interaction as major. Macimorelin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and mifepristone may also raise macimorelin concentrations through CYP3A4 inhibition. The combination increases the risk of torsade de pointes.
How serious is the interaction between Macimorelin and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination during macimorelin testing. Allow adequate washout of mifepristone before the test, and use an alternative diagnostic approach if needed.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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