Drug interactions
Macimorelin + Primaquine
Severity: Major
Macimorelin and Primaquine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin can prolong the QT interval, and primaquine may add to this effect. The combination may raise the risk of torsades de pointes during the diagnostic test.
What this interaction means in plain words
Macimorelin and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Primaquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation.
What to do
Avoid macimorelin testing while the patient is taking primaquine or delay it until primaquine is stopped. If unavoidable, obtain an ECG and correct electrolytes first.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Primaquine?
MediHelp rates the interaction as major. Macimorelin and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin can prolong the QT interval, and primaquine may add to this effect. The combination may raise the risk of torsades de pointes during the diagnostic test.
How serious is the interaction between Macimorelin and Primaquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid macimorelin testing while the patient is taking primaquine or delay it until primaquine is stopped. If unavoidable, obtain an ECG and correct electrolytes first.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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