Drug interactions
Macimorelin + Propafenone
Severity: Moderate
Macimorelin and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small increase in the QT interval, and propafenone can prolong conduction and has proarrhythmic effects. Combined use could raise the risk of torsades de pointes during the diagnostic test.
What this interaction means in plain words
Macimorelin and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Propafenone belongs to Cardiovascular.
Why it happens
Additive QT prolongation.
What to do
Avoid giving macimorelin to patients taking propafenone, or defer the test until propafenone has been cleared if clinically feasible. If it is done, perform ECG monitoring and check electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Propafenone?
MediHelp rates the interaction as moderate. Macimorelin and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin causes a small increase in the QT interval, and propafenone can prolong conduction and has proarrhythmic effects. Combined use could raise the risk of torsades de pointes during the diagnostic test.
How serious is the interaction between Macimorelin and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving macimorelin to patients taking propafenone, or defer the test until propafenone has been cleared if clinically feasible. If it is done, perform ECG monitoring and check electrolytes.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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