Drug interactions
Macimorelin + Quetiapine
Severity: Moderate
Macimorelin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small rise in QTc and quetiapine can also prolong QT. Combined use could increase the risk of torsades de pointes during testing.
What this interaction means in plain words
Macimorelin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Where feasible, hold quetiapine for a sufficient washout before the macimorelin test. If not possible, consider another growth hormone stimulation test.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Quetiapine?
MediHelp rates the interaction as moderate. Macimorelin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin causes a small rise in QTc and quetiapine can also prolong QT. Combined use could increase the risk of torsades de pointes during testing.
How serious is the interaction between Macimorelin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, hold quetiapine for a sufficient washout before the macimorelin test. If not possible, consider another growth hormone stimulation test.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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