Drug interactions
Macimorelin + Quinidine
Severity: Major
Macimorelin and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin modestly prolongs the QT interval and quinidine does so strongly, so combining them increases the risk of torsades de pointes. Because macimorelin is used for a single diagnostic test, the exposure window is brief but still relevant.
What this interaction means in plain words
Macimorelin and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Additive QT interval prolongation.
What to do
Avoid macimorelin testing while the patient is taking quinidine, and allow adequate washout of quinidine before testing. Consider another diagnostic approach if quinidine cannot be stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Quinidine?
MediHelp rates the interaction as major. Macimorelin and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin modestly prolongs the QT interval and quinidine does so strongly, so combining them increases the risk of torsades de pointes. Because macimorelin is used for a single diagnostic test, the exposure window is brief but still relevant.
How serious is the interaction between Macimorelin and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid macimorelin testing while the patient is taking quinidine, and allow adequate washout of quinidine before testing. Consider another diagnostic approach if quinidine cannot be stopped.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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