Drug interactions
Macimorelin + Rifampicin
Severity: Moderate
Macimorelin and Rifampicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin may lower macimorelin levels and reduce the stimulation of growth hormone release. This can produce false-positive results in growth hormone deficiency testing.
What this interaction means in plain words
Macimorelin and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Rifampicin belongs to Anti Bacterial.
Why it happens
Strong CYP3A4 induction by rifampicin increases macimorelin metabolism.
What to do
Stop rifampicin before macimorelin testing, allowing enough time for induction to resolve. Delay the test if rifampicin cannot be stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Macimorelin
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Macimorelin with Rifampicin?
MediHelp rates the interaction as moderate. Macimorelin and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin may lower macimorelin levels and reduce the stimulation of growth hormone release. This can produce false-positive results in growth hormone deficiency testing.
How serious is the interaction between Macimorelin and Rifampicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop rifampicin before macimorelin testing, allowing enough time for induction to resolve. Delay the test if rifampicin cannot be stopped.
What other medicines interact with Macimorelin?
MediHelp also lists interactions of Macimorelin with, for example, Alfuzosin, Amiodarone, Amisulpride. The full list is on the Macimorelin page.
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