Drug interactions
Macimorelin + Sertraline
Severity: Moderate
Macimorelin and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small increase in the QTc interval, and combining it with other QT-prolonging drugs may raise the risk of torsade de pointes. Sertraline has a modest QT effect at usual doses.
What this interaction means in plain words
Macimorelin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Sertraline belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarisation.
What to do
Where feasible, hold sertraline before the macimorelin test per labeling guidance, or ensure ECG monitoring and normal electrolytes. Avoid the test if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Sertraline?
MediHelp rates the interaction as moderate. Macimorelin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin causes a small increase in the QTc interval, and combining it with other QT-prolonging drugs may raise the risk of torsade de pointes. Sertraline has a modest QT effect at usual doses.
How serious is the interaction between Macimorelin and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, hold sertraline before the macimorelin test per labeling guidance, or ensure ECG monitoring and normal electrolytes. Avoid the test if other QT risk factors are present.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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