Drug interactions
Macimorelin + Thioridazine
Severity: Major
Macimorelin and Thioridazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small increase in QTc, and thioridazine strongly prolongs QT. Used together they raise the risk of torsades de pointes during the diagnostic test.
What this interaction means in plain words
Macimorelin and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Thioridazine belongs to Central Nervous System.
Why it happens
Additive prolongation of ventricular repolarization (QT).
What to do
Avoid coadministration and allow adequate washout of thioridazine before macimorelin testing. If unavoidable, monitor ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Thioridazine?
MediHelp rates the interaction as major. Macimorelin and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes a small increase in QTc, and thioridazine strongly prolongs QT. Used together they raise the risk of torsades de pointes during the diagnostic test.
How serious is the interaction between Macimorelin and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and allow adequate washout of thioridazine before macimorelin testing. If unavoidable, monitor ECG.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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