Drug interactions
Macimorelin + Vardenafil
Severity: Moderate
Macimorelin and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin prolongs the QT interval and its label advises against use with other QT-prolonging drugs. Vardenafil has a small QT effect that could add to the arrhythmia risk during testing.
What this interaction means in plain words
Macimorelin and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Vardenafil belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Withhold vardenafil for a sufficient washout period before macimorelin testing. Resume it after the test is complete.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Macimorelin and Vardenafil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Vardenafil?
MediHelp rates the interaction as moderate. Macimorelin and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin prolongs the QT interval and its label advises against use with other QT-prolonging drugs. Vardenafil has a small QT effect that could add to the arrhythmia risk during testing.
How serious is the interaction between Macimorelin and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold vardenafil for a sufficient washout period before macimorelin testing. Resume it after the test is complete.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
