Drug interactions
Macimorelin + Ziprasidone
Severity: Major
Macimorelin and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin modestly prolongs the QT interval and ziprasidone is a known QT-prolonging antipsychotic. Used together, they raise the risk of torsades de pointes during the diagnostic test.
What this interaction means in plain words
Macimorelin and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive delayed cardiac repolarization through hERG channel inhibition.
What to do
Avoid giving macimorelin to patients taking ziprasidone. Allow an adequate washout of ziprasidone before testing, or use an alternative diagnostic approach.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Ziprasidone?
MediHelp rates the interaction as major. Macimorelin and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin modestly prolongs the QT interval and ziprasidone is a known QT-prolonging antipsychotic. Used together, they raise the risk of torsades de pointes during the diagnostic test.
How serious is the interaction between Macimorelin and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving macimorelin to patients taking ziprasidone. Allow an adequate washout of ziprasidone before testing, or use an alternative diagnostic approach.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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