Drug interactions
Magnesium + Trientine
Severity: Moderate
Magnesium and Trientine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium supplements can bind trientine in the gut and reduce its absorption, potentially lessening copper removal.
What this interaction means in plain words
Magnesium and Trientine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium belongs to Gastrointestinal Tract; Trientine belongs to Miscellaneous.
Why it happens
Chelation of trientine by magnesium reduces gastrointestinal absorption.
What to do
Separate dosing: trientine at least 1 hour before or 2 hours after magnesium. Monitor copper indices.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trientine
- Calcium + Trientine Moderate
- Carbonyl iron + Trientine Moderate
- Copper + Trientine Moderate
- Ferrous fumarate + Trientine Moderate
- Ferrous gluconate + Trientine Moderate
- Ferrous sulfate + Trientine Moderate
Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Frequently asked questions
Can I take Magnesium with Trientine?
MediHelp rates the interaction as moderate. Magnesium and Trientine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium supplements can bind trientine in the gut and reduce its absorption, potentially lessening copper removal.
How serious is the interaction between Magnesium and Trientine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate dosing: trientine at least 1 hour before or 2 hours after magnesium. Monitor copper indices.
What other medicines interact with Trientine?
MediHelp also lists interactions of Trientine with, for example, Calcium, Carbonyl iron, Copper. The full list is on the Trientine page.
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