Drug interactions
Magnesium hydroxide + Pexidartinib
Severity: Moderate
Magnesium hydroxide and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids that act locally raise gastric pH and may reduce pexidartinib absorption, potentially lowering its efficacy. The interaction is mainly relevant with acid-reducing agents.
What this interaction means in plain words
Magnesium hydroxide and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium hydroxide belongs to Gastrointestinal Tract; Pexidartinib belongs to Oncology.
Why it happens
Increased gastric pH from the antacid reduces pH-dependent dissolution and absorption of pexidartinib.
What to do
Take pexidartinib at least 2 hours before or 2 hours after magnesium hydroxide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium hydroxide
Other interactions of Pexidartinib
Frequently asked questions
Can I take Magnesium hydroxide with Pexidartinib?
MediHelp rates the interaction as moderate. Magnesium hydroxide and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids that act locally raise gastric pH and may reduce pexidartinib absorption, potentially lowering its efficacy. The interaction is mainly relevant with acid-reducing agents.
How serious is the interaction between Magnesium hydroxide and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take pexidartinib at least 2 hours before or 2 hours after magnesium hydroxide.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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