Drug interactions
Magnesium hydroxide + Riociguat
Severity: Moderate
Magnesium hydroxide and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids containing aluminum or magnesium can reduce the oral absorption of riociguat. Lower exposure may reduce its benefit in pulmonary hypertension.
What this interaction means in plain words
Magnesium hydroxide and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium hydroxide belongs to Gastrointestinal Tract; Riociguat belongs to Cardiovascular.
Why it happens
Raised gastric pH and binding by antacid cations reduce the dissolution and absorption of riociguat.
What to do
Give riociguat at least 1 hour before or after magnesium hydroxide. Monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium hydroxide
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Magnesium hydroxide with Riociguat?
MediHelp rates the interaction as moderate. Magnesium hydroxide and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids containing aluminum or magnesium can reduce the oral absorption of riociguat. Lower exposure may reduce its benefit in pulmonary hypertension.
How serious is the interaction between Magnesium hydroxide and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give riociguat at least 1 hour before or after magnesium hydroxide. Monitor clinical response.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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