Drug interactions
Magnesium hydroxide + Sarecycline
Severity: Moderate
Magnesium hydroxide and Sarecycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium-containing antacids can bind sarecycline in the gut and reduce absorption, possibly decreasing its antibacterial effect, though sarecycline is less affected than older tetracyclines.
What this interaction means in plain words
Magnesium hydroxide and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium hydroxide belongs to Gastrointestinal Tract; Sarecycline belongs to Anti Bacterial.
Why it happens
Chelation of sarecycline by magnesium cations reduces its GI absorption.
What to do
Separate sarecycline from magnesium products by at least 2 to 3 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium hydroxide
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Magnesium hydroxide with Sarecycline?
MediHelp rates the interaction as moderate. Magnesium hydroxide and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium-containing antacids can bind sarecycline in the gut and reduce absorption, possibly decreasing its antibacterial effect, though sarecycline is less affected than older tetracyclines.
How serious is the interaction between Magnesium hydroxide and Sarecycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate sarecycline from magnesium products by at least 2 to 3 hours.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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