Drug interactions
Magnesium sulphate + Methyclothiazide
Severity: Minor
Magnesium sulphate and Methyclothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methyclothiazide increases urinary magnesium loss and can cause hypomagnesemia with prolonged use. This may lessen the effect of magnesium therapy and increase arrhythmia risk, especially with concurrent hypokalemia.
What this interaction means in plain words
Magnesium sulphate and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazides increase renal magnesium excretion.
What to do
Monitor serum magnesium and potassium during long-term combined therapy, and replace as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Frequently asked questions
Can I take Magnesium sulphate with Methyclothiazide?
MediHelp rates the interaction as minor. Magnesium sulphate and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methyclothiazide increases urinary magnesium loss and can cause hypomagnesemia with prolonged use. This may lessen the effect of magnesium therapy and increase arrhythmia risk, especially with concurrent hypokalemia.
How serious is the interaction between Magnesium sulphate and Methyclothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and potassium during long-term combined therapy, and replace as needed.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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