Drug interactions
Maprotiline + Osimertinib
Severity: Moderate
Maprotiline and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Their combination may raise the risk of torsades de pointes, particularly with electrolyte disturbances, bradycardia or underlying heart disease.
What this interaction means in plain words
Maprotiline and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization through effects on cardiac ion channels.
What to do
Obtain a baseline ECG and periodically monitor QTc and electrolytes, correcting potassium and magnesium abnormalities. Consider an alternative antidepressant if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Maprotiline with Osimertinib?
MediHelp rates the interaction as moderate. Maprotiline and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval. Their combination may raise the risk of torsades de pointes, particularly with electrolyte disturbances, bradycardia or underlying heart disease.
How serious is the interaction between Maprotiline and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and periodically monitor QTc and electrolytes, correcting potassium and magnesium abnormalities. Consider an alternative antidepressant if QTc becomes markedly prolonged.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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