Drug interactions
Maprotiline + Papaverine
Severity: Minor
Maprotiline and Papaverine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaverine has little clinically established sedative effect, so the claimed additive sedation is weak. Both agents can contribute to hypotension, and papaverine has been rarely associated with conduction effects. No well-documented interaction exists.
What this interaction means in plain words
Maprotiline and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maprotiline belongs to Central Nervous System; Papaverine belongs to Cardiovascular.
Why it happens
No established mechanism; possible minor additive vasodilatory or hypotensive effects.
What to do
No routine action is needed beyond monitoring blood pressure and sedation when starting the combination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Maprotiline with Papaverine?
MediHelp rates the interaction as minor. Maprotiline and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Papaverine has little clinically established sedative effect, so the claimed additive sedation is weak. Both agents can contribute to hypotension, and papaverine has been rarely associated with conduction effects. No well-documented interaction exists.
How serious is the interaction between Maprotiline and Papaverine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed beyond monitoring blood pressure and sedation when starting the combination.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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