Drug interactions
Maprotiline + Phentermine
Severity: Major
Maprotiline and Phentermine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine is an indirect sympathomimetic, and maprotiline affects norepinephrine reuptake. Together they may cause hypertension, tachycardia, arrhythmia and agitation, and possibly serotonergic toxicity.
What this interaction means in plain words
Maprotiline and Phentermine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Maprotiline belongs to Central Nervous System; Phentermine belongs to Central Nervous System.
Why it happens
Maprotiline inhibits norepinephrine reuptake and uptake of indirect sympathomimetics, altering and potentially increasing the response to phentermine.
What to do
Avoid the combination when feasible. If both are needed, monitor blood pressure, heart rate and mental status, and use the lowest effective doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Maprotiline with Phentermine?
MediHelp rates the interaction as major. Maprotiline and Phentermine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phentermine is an indirect sympathomimetic, and maprotiline affects norepinephrine reuptake. Together they may cause hypertension, tachycardia, arrhythmia and agitation, and possibly serotonergic toxicity.
How serious is the interaction between Maprotiline and Phentermine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when feasible. If both are needed, monitor blood pressure, heart rate and mental status, and use the lowest effective doses.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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