Drug interactions
Maprotiline + Ribociclib
Severity: Major
Maprotiline and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib causes concentration-dependent QT prolongation, and maprotiline can also prolong the QT interval. Co-administration increases the risk of torsades de pointes. Ribociclib also inhibits CYP3A4 and may modestly affect other drugs.
What this interaction means in plain words
Maprotiline and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Maprotiline belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Avoid the combination and select an antidepressant with less QT effect. If it cannot be avoided, monitor ECG and electrolytes at baseline and during treatment, and interrupt or reduce ribociclib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Maprotiline with Ribociclib?
MediHelp rates the interaction as major. Maprotiline and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib causes concentration-dependent QT prolongation, and maprotiline can also prolong the QT interval. Co-administration increases the risk of torsades de pointes. Ribociclib also inhibits CYP3A4 and may modestly affect other drugs.
How serious is the interaction between Maprotiline and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select an antidepressant with less QT effect. If it cannot be avoided, monitor ECG and electrolytes at baseline and during treatment, and interrupt or reduce ribociclib if QTc becomes markedly prolonged.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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