Drug interactions
Maprotiline + Rilpivirine
Severity: Moderate
Maprotiline and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine at supratherapeutic doses prolongs the QT interval, and maprotiline can also prolong QTc. Combined use may increase the risk of torsades de pointes, especially with electrolyte disturbances or heart disease.
What this interaction means in plain words
Maprotiline and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Rilpivirine belongs to Anti Virals.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes, correcting hypokalemia and hypomagnesemia. Consider an alternative antidepressant in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Maprotiline with Rilpivirine?
MediHelp rates the interaction as moderate. Maprotiline and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine at supratherapeutic doses prolongs the QT interval, and maprotiline can also prolong QTc. Combined use may increase the risk of torsades de pointes, especially with electrolyte disturbances or heart disease.
How serious is the interaction between Maprotiline and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes, correcting hypokalemia and hypomagnesemia. Consider an alternative antidepressant in patients with other QT risk factors.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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