Drug interactions
Maprotiline + Solifenacin
Severity: Moderate
Maprotiline and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline can prolong the QT interval and has substantial antimuscarinic activity. Combining it with solifenacin increases the risk of arrhythmia and of anticholinergic toxicity such as retention, confusion and constipation.
What this interaction means in plain words
Maprotiline and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation and additive antimuscarinic effects.
What to do
Avoid combining where an alternative is available. If used together, monitor the ECG and anticholinergic symptoms, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Solifenacin?
MediHelp rates the interaction as moderate. Maprotiline and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline can prolong the QT interval and has substantial antimuscarinic activity. Combining it with solifenacin increases the risk of arrhythmia and of anticholinergic toxicity such as retention, confusion and constipation.
How serious is the interaction between Maprotiline and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where an alternative is available. If used together, monitor the ECG and anticholinergic symptoms, particularly in older patients.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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