Drug interactions
Maprotiline + Succinylcholine
Severity: Minor
Maprotiline and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline has anticholinergic properties, but there is no established antagonism of succinylcholine blockade. Tetracyclic antidepressants may contribute to arrhythmias and hemodynamic instability under anesthesia. Documented interaction specific to succinylcholine is limited.
What this interaction means in plain words
Maprotiline and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maprotiline belongs to Central Nervous System; Succinylcholine belongs to Musculoskeletal.
Why it happens
No established mechanism; possible additive cardiovascular effects.
What to do
Monitor ECG and blood pressure during induction. Monitor neuromuscular blockade with a nerve stimulator.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Maprotiline and Succinylcholine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Succinylcholine
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Succinylcholine?
MediHelp rates the interaction as minor. Maprotiline and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maprotiline has anticholinergic properties, but there is no established antagonism of succinylcholine blockade. Tetracyclic antidepressants may contribute to arrhythmias and hemodynamic instability under anesthesia. Documented interaction specific to succinylcholine is limited.
How serious is the interaction between Maprotiline and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and blood pressure during induction. Monitor neuromuscular blockade with a nerve stimulator.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
